Design, Development and Evaluation of Clozapine Loaded Mucoadhesive Microspheres using Natural Crosslinker for Brain Drug Delivery

Abstract

Schizophrenia is a severe and most dangerous form of a mental illness. About 21 million people affected by this mental disorder worldwide. Proportion of Male to Female schizophrenia affected patients are 12 million to 9 million respectively. The chronic nature of schizophrenia revealed by some key characteristics such as disturbance in thought process, mental imbalance and emotional dysregulation¹. Conventional dosage forms and treatments are available for schizophrenia but it was found that patients require high standard care during the treatment.